Beta Nicotinamide Mononucleotide

Beta Nicotinamide mononucleotide (NMN) is an intermediate of NAD+ biosynthesis produced from nicotinamide through nicotinamide phosphoribosyltransferase (NAMPT) and also referred to as NMN or nicotinamide ribotide. In recent studies of NMN applications to prevention and diagnosis of age-dependent diseases such as diabetes, neurodegenerative disorder, cardiac disease etc., it has become one of hottest biomarkers on discussion for anti-aging.

β-nicotinamide mononucleotide(NMN), a product of the NAMPT reaction and a key NAD+ intermediate, ameliorates glucose intolerance by restoring NAD+ levels in HFD-induced T2D mice. NMN also enhances hepatic insulin sensitivity and restores gene expression related to oxidative stress, inflammatory response, and circadian rhythm, partly through SIRT1 activation. NMN is used for studying binding motifs within RNA aptamers and ribozyme activation processes involving β-nicotinamide mononucleotide (β-NMN)-activated RNA fragments. It is to be used for research only.

Certificate of Analysis:

Beta Nicotinamide Mononucleotide Benefits

β-Nicotinamide mononucleotide (NMN) is used to study binding motifs within RNA aptamers and ribozyme activation processes involving β-nicotinamide mononucleotide (β-NMN)-activated RNA fragments.

1.NMN MAY HELP PROMOTE CARDIOVASCULAR FUNCTION

One of the most evident effects of NMN in research studies are it’s effects on our cardiovascular system and blood flow in general. Within the cardiovascular system, NMN can quickly turn into NAD+, which is a very important molecule for cardiovascular support. NAD+ helps fuel the function of SIRT1, a highly important enzyme which requires NAD+ to function.

2.NMN MAY HELP PROMOTE ENERGY LEVELS

One of the things Beta Nicotinamide Mononucleotide (NMN) is most widely known for, is its ability to help promote energy levels in both young and older individuals. NMN achieves this via a few different mechanisms and NMN’s energy promoting effects appear to be one of the most consistent and noticeable effects NMN can produce, as it is mentioned in almost every anecdotal report of NMN supplementation.

3.NMN MAY HELP PROMOTE SLEEP QUALITY

Now this is a bit of a strange one, right? Why would an energy promoting supplement also help promote sleep? Well, this is not entirely uncommon. For example we have found that Uridine may help promote energy levels, but it may also help promote sleep quality. This is why we formulated our sleep support formula with Uridine. With NMN however, it is somewhat unclear as to how it is helping promote sleep quality but we do have some solid leads. Fair warning, this is about to get a little bit complex, but this may also be the first time this topic has been discussed in much detail besides loose anecdotal reports.

4.NMN MAY HELP PROMOTE LONGEVITY

This section is going to be a bit of a summary of all of the sections in this blog. This is due to the fact that the longevity promoting effects of NMN are rooted in its ability to promote cardiovascular function, sleep quality and energy metabolism. Overall, it appears that the most important aspect of NMN promoting longevity is it’s ability to promote NAD+ levels and thereby Sirtuin function. It appears that NAD+ levels decline as we age, and thereby any function in our body that is being supported by NAD+ may not work as well. By replenishing our bodies with NAD+ by taking an Beta-Nicotinamide Mononucleotide(NMN) supplement, we can help support these vital processes that rely on adequate NAD+ levels. In theory, this should support overall longevity. Furthermore, it should also help promote better quality of life as we age.

5.NMN MAY HELP PROMOTE A POSITIVE MOOD

Besides anecdotal reports of improvements in energy levels and sleep quality, another commonly reported effect of taking an NMN supplement is finding yourself in a more positive mood. Lucky for us, this one is very easy to explain, unlike the reported sleep effects!

Application of Beta Nicotinamide Mononucleotide :

The coenzyme NAD and its derivatives are involved in hundreds of metabolic redox reactions and are utilized in protein ADP-ribosylation, histone deacetylation, and in some Ca2+ signaling pathways. NMNAT (EC 2.7.7.1) is a central enzyme in NAD biosynthesis, catalyzing the condensation of nicotinamide mononucleotide (NMN) or nicotinic acid mononucleotide (NaMN) with the AMP moiety of ATP to form NAD or NaAD.

NMNAT1 is the most widely expressed of three orthologous genes with nicotinamide-nucleotide adenylyltransferase (NMNAT) activity. Genetically engineered mice lacking NMNAT1 die during early embryogenesis, indicating a critical role of this gene in organismal viability.[citation needed] In contrast, mice lacking NMNAT2, which is expressed predominantly in neural tissues, complete development but die shortly after birth. However, NMNAT1 is dispensable for cell viability, as homozygous deletion of this gene occurs in glioblastoma tumors and cell lines. NMNAT enzymatic activity is probably essential at the cellular level, as complete ablation of NMNAT activity in model organisms leads to cellular inviability.

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Coconut oil/ Palm Kernel Oil→Emulsified homogenization→Embedding reinforcement→Cold spray drying→first rejuvenation→Secondary recombination dry forming→inspection→package→in stock