Grape Seed Extract Bulk

Latin Name:Vitis Vinifera L

Appearance:Reddish Brown Fine Powder

Active Ingredients:Polyphenols; OPC

Proanthocyanidins 95% UV

Polyphenols 80%, 85%, 90%, 95% UV

Water soluble Proanthocyanidins 95% UV

Proanthocyanidins/ Oligomers 95%UV/ 60%HPLC

Specification: OPC 95%;

Certifications: ISO,KOSHER,Halal,Organic;

Stock in LA USA warehouse;

What is Grape Seed Extract Bulk?Grape seed extract bulk is derived from the ground up grape seeds used to manufacture red wine.Grape seed extract may help with a type of poor circulation (chronic venous insufficiency) and high cholesterol. Grape seed extract also reduces swelling caused by injury and helps with eye disease related to diabetes.
Many people are interested in grape seed extract because it contains antioxidants. These are substances that protect cells from damage and may help prevent many diseases.Grapes are native to Asia and were later introduced to Europe and North America, where many red, green and purple varieties are now cultivated.
Bulk grape seed extract (GSE) has been scientifically proven to lower blood pressure and reduce the risk of heart disease. GSE is considered safe by the FDA and any serious side effects have not been reported.
GSE is an antioxidant that researchers support as boosting cardiac health. Proanthocyanidins are antioxidant compounds in grape seed extract bulk, reportedly 50 times more effective than vitamin C for hampering free radicals. The supplement also contains flavonoids, vitamin E and linoleic acids.Basic Information:
Product nameGrape Seed Extract BulkLatin nameVitis vinifera L.Part usedSeedsHarvest seasonAutumnExtraction TypeSolvent ExtractionActive IngrdientsProanthocyanidins (monomers, oligomers, polymers)Cas No4852-22-6Molecular FormulaC30H26O13Formula Weight594.52Synonymsgrape seed extract, grape seed extract powder, grape seed extract capsule, grape seed oil extract, grape seed extract softgel capsule,OPC, ProanthocyanidinsTest MethodUV, HPLCFormula Structure
ProanthocyanidinsSpecificationsProanthocyanidins: 95% Red brown fine powderPolyphenols: 70-95% Red brown fine powder
Grape Seed Benefits:1) Circulatory and Vein HealthIn 36 subjects, one-month supplementation with grape seed extract (2 g daily) protected blood vessels against free-radical damage by boosting nitric oxide.In a series of smaller clinical trials (130 people in total), grape seed extract lowered the risk of heart disease by lowering oxidative stress and inflammation. It prevented the oxidation of LDL (“bad cholesterol”) in the blood vessels. Oxidized LDL can trigger plaque buildup or atherosclerosis.

2) High Blood LipidsIn a meta-analysis of nine clinical trials with 390 participants, grape seed extract had no effect on blood lipid levels and C-reactive protein (CRP), a marker of inflammation.The following purported benefits are only supported by limited, low-quality clinical studies. There is insufficient evidence to support the use of grapeseed for any of the below-listed uses.
3) Cognitive DeclineIn over 100 older patients, supplementation with grape seed extract enhanced cognition and reduced the symptoms of stress and depression. In animal and cell studies, these extracts protected brain cells against oxidative damage and death triggered by different toxins. The National Center for Complementary and Integrative Health supports preliminary research on grape seed extract for Alzheimer’s disease.
4) Wound HealingIn 40 patients recovering from a surgery, grape seed extract 2% cream enhanced wound healing by stimulating VEGF production, blocking oxidative damage, and fighting microbes.It showed the same effect in two animal studies. Grape seed extract ointment (5%) significantly improved wound healing after C-section in a trial of 129 women. In a few clinical studies, creams and ointments containing grape seed extract appeared to improve wound healing.
5) Liver ProtectionIn 15 patients with fatty liver, grape seed extract dropped liver enzymes and reversed fat buildup. It showed better results than vitamin C. But such a small sample prevents us from drawing firm conclusions from this study.Grape seed extract is believed to be beneficial for the liver, but most of the evidence for this comes from animal studies.6) Kidney ProtectionIn a clinical trial of 33 patients with kidney disease, grape seed extract enhanced kidney function by providing antioxidant and anti-inflammatory support. This study had a small sample size and uneven randomization, making the results questionable. In animals, grape seed extract protected the kidneys from toxic drugs and high cholesterol. It worked by [60, 61, 62]: Limited clinical evidence suggests that grape seed extract may support kidney function.7) Hair LossGrape seeds contain procyanidins—powerful antioxidants that support hair growth. An extract of procyanidins (from Annurca apple) boosted hair growth in a trial on 250 men. Still, this doesn’t mean that grape seed procyanidins would achieve the same [63]. Grape seed extract and isolated procyanidins stimulated the hair follicles and enhanced hair growth in different animal and cell-based studies [64, 65, 66, 67].
8) Weight LossMany supplements are promoted to stimulate weight loss, but none of them has yet been supported by strong clinical evidence and approved by the health authorities. A healthy, calorie-controlled diet and increased physical activity remain the only proven strategies for weight control.In 51 overweight patients, grape seed extract slightly reduced food intake but didn’t impact appetite. This study lasted only three days and had a small sample size [69].
Well-designed clinical trials should clear up the conflicting effects of grape seed extract on weight loss and fat burning.
9) Benefits for the SkinUV ProtectionModerate sunbathing is essential for your vitamin D production and overall health and wellbeing. On the other hand, excess UV exposure may cause sunburns and skin damage [75].
The skin of 10 volunteers treated with grape seed extract before UV exposure had fewer mutated and damaged cells and more healthy ones. However, the lack of placebo control and a tiny sample minimize the relevance of this clinical study. The extract also prevented UV-induced skin cancer by blocking oxidative damage and inflammation in many animal trials [77, 78, 79, 80, 81].
Skin AgingIn 12 women, supplementation with grape seed extract (200 mg daily for 6 months) lightened the skin and reduced face spots. Its combination with other antioxidants improved skin complexion in 35 women. They were able to get rid of dark circles, face spots, and other skin imperfections. The majority of women (82%) were satisfied with the results [83]. In a handful of very small clinical studies, grape seed creams and supplementation improved skin damage due to UV light and aging.
10) Reproductive Health and Testosterone LevelsIn male rats, grape seed extract recovered testosterone levels and prevented testicular damage caused by [84, 85, 86, 87, 88]:According to some animal studies, grape seed extract can inhibit an enzyme called aromatase, which converts male sex hormones (androgens) to female sex hormones (estrogens). This effect could, in theory, raise the levels of testosterone and protect against breast cancer.
11) DiabetesIn diabetic rats, grape seed extract lowered blood glucose, cholesterol, and lipids while boosting insulin secretion and antioxidant support. The extract had the same effects on animals with insulin resistance caused by a high-sugar diet. It prevented blood glucose spikes and restored antioxidant enzymes. Grape seed extract has demonstrated multiple benefits for diabetic animals, but this research has not been applied to humans.12) Joint and Bone HealthIn rats and mice with rheumatoid arthritis, grape seed extract improved symptoms and reduced autoimmune joint destruction. It lowered the levels of inflammatory molecules (TNF-a, IL-17, IL-21, ICAM-1) and silenced Th1 and Th17 autoimmune responses [102, 103, 104, 105, 106]. In another study, it protected rats against a different joint disease, osteoarthritis. The extract reduced joint pain and cartilage degradation [107]. Additionally, grape seed extract strengthened the bones and boosted their growth in several rat studies [108, 109, 110, 111].In animal studies, grape seed extract reduced tissue destruction in rheumatoid arthritis and osteoarthritis, strengthened bones, and reduced joint pain.
13) Inflammatory Bowel Disease (IBD)Widespread autoimmune inflammation and oxidative stress cause severe gut damage in Crohn’s disease and ulcerative colitis, the two main forms of IBD. Dietary antioxidants are being researched as a complementary approach to IBD.14) Asthma and AllergiesGrape seed extract relieved airway inflammation (IL-4, IL-5, IL-13, iNOS), IgE immune response, and mucus production in asthmatic rats [117, 118, 119].15) Antibacterial ActivityLipopolysaccharides (LPS) from the cell wall of gram-negative bacteria (Escherichia, Salmonella, Pseudomonas, etc.) can trigger inflammation and cause different symptoms of bacterial infections.Grape seed extract controlled the inflammatory response (NOx, IL-6, iNOS) and boosted glutathione in rats infected with LPS [122].

Application :Food field1. It can be made into capsules, troche and granule as healthy food.2. High quality Grape seed extract, which has good solubility in water and ethanol plus the solution transparence and brilliance color, has been widely added into the beverage and the wine, cosmetics as the functional content.3. For the function of the strong anti-oxidant, it is widely added into all kinds of foods such as cake, cheese as the nurture, natural antiseptic in Europe and USA, and it has increased the safety of the food.
Health care fieldProanthocyanidins in it is thiry to fifty times as effective as Vitamin C and Vitamin E ,it can be used to protecting the heart and bloodvessel,improving retinopathy caused by diabetics, atherosclerosis, inflammation and aging,improvingathletic performance, memory and healthy lifestyle,preventing and reversing Alzheimer Disease,improving sexual function, PMS and menstrual disorders and helping to treat ADD/ADHDCosmetic fieldIt is one of the most powerful antioxidants that fights free radicals,It can maintain the elasticity and water of the skin, delaying the appearance of .the wrinkles,anti-aging and anti-wrinkle.anti-cancer, anti-inflammation and anti-allergic activity.
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