Product Name:Honokiol Extract
Latin Name: Magnolia officinalis Rehd.Et Wils;
Specification Ratio: 4:1~20:1;
Appearance: Yellow to off -white Powder;
Test Method: TLC / HPLC;
Main Function: It has special and lasting muscle relaxation and strong antibacterial effect;
Certificate: KOSHER, HALAL, ISO,ORGANIC CERTIFICATE;
What is Honokiol Extract?Honokiol extract is a lignan isolated from the bark, seed cones, and leaves of trees belonging to the genus Magnolia. It has been identified as one of the chemical compounds in some traditional eastern herbal medicines along with magnolol, 4-O-methylhonokiol, and obovatol.
Honokiol extract has been extracted from a number of species of Magnolia native to many regions of the globe. Magnolia grandiflora, which is native to the American South, as well as Mexican species like Magnolia dealbata have been found to be sources of honokiol. Traditionally in Asian medicine, the Magnolia biondii, Magnolia obovata, and Magnolia officinalis are commonly used. The compound itself has a spicy odor.
Because of its physical properties, honokiol can readily cross the blood brain barrier and the blood-cerebrospinal fluid barrier.As a result, honokiol is a potentially potent therapy with high bioavailability.
DescriptionYellowish brown or white powderCompliesAssayMagnolol 98% (HPLC)98.32%Mesh Size100 % pass 80 meshCompliesAsh≤ 5.0%2.85%Chemical Analysis
Heavy Metal≤ 10.0 mg/kgCompliesPb≤ 2.0 mg/kgCompliesAs≤ 1.0 mg/kgCompliesMicrobiological Analysis
Residue of PesticideNegativeNegativeTotal Plate Count≤ 1000cfu/gCompliesYeast&Mold≤ 100cfu/gComplies
Honokiol Extract (98% Honokiol) BenefitsHonokiol extract is a poly-phenolic compound that exerts neuroprotective properties through a variety of mechanisms. It has therapeutic potential in anxiety, pain, cerebrovascular injury, epilepsy, and cognitive disorders including Alzheimer’s disease.Neuroprotection
In terms of Alzheimer’s disease, honokiol has been proven to be effective in preventing neuronal cell death. In various studies conducted, results show that the extract can rescue neuronal cells against oxidative stress especially during the early stages of Alzheimer’s disease. It is able to delay the symptoms by rescuing the mitochondrial functions of the brain.
Magnolia bark which contains honokiol extract has long been used for its natural calming remedy. It works as an anxiety reducer claiming that it helps “turn off their brain” and prevent it from overworking. The ability to decrease anxiety-related behavior comes from its ability to activate receptors in the endocannabinoid system, reducing adrenaline, and other stress-related hormones like cortisol.
Compared with other anti-anxiety prescription drugs which can lead to physical dependence and central depression, it was observed that the administration of honokiol showed to be effective among laboratory animals. Oral administration of honokiol leads significantly better results compared with oral diazepam which may pose cognitive side effects. This finding opens potential possibilities of using the extract to effectively treat different anxiety disorders among humans.
Anti-depressantPatients suffering from depression have been observed to have low levels of serotonin. Serotonin is an important chemical neurotransmitter in the body. It is sometimes called the happy hormone because it is associated with vibrant and alive feelings after doing exercise, eating chocolates, and during happy situations. Its main function is to regulate mood and social behavior. When there is a chemical imbalance of serotonin, this leads to a depressed attitude.
Mixtures of pure honokiol extract and magnolol from magnolia bark have been observed to possess anti-depressant effects among stressed rodents. The mechanism of action is linked to its ability to normalize the level of serotonin in the blood. By taking honokiol, patients are able to correct the imbalances of chemicals thereby reducing the symptoms of depression.
Sleep disorders are commonly observed along with other mental disorders like depression and anxiety. Depressed and anxious patients suffer from low quality and sleep disturbances at night which often worsens their condition. Studies show that when patients manage the symptoms of anxiety and depression using magnolia extract honokiol, it also indirectly treats sleep disorders. The mechanism comes from its ability to excite the sleep-promoting neurons. When tested among mice with induced sleep disorders, research shows that it can accelerate the initiation of NREM (non-rapid eye movement) sleep. The effects lasted for 4 hours at a dose of 20 mg. The overall conclusion was that honokiol is useful as a sleep-promoting substance especially insomnia related to depression and anxiety.
Pain and InflammationPain and inflammation are common symptoms of chronic disorders like arthritis. While the two have protective roles, the associated process leads to uncomfortable feelings. Although a number of drugs are available, many of these have dose-limiting side effects. The medications are also expensive, addictive, and have long-term deleterious side effects. Thus, many health care practitioners resort to herbal drugs to manage pain and inflammation. They are as effective as synthetic drugs but they are more natural and safer alternatives.
One very common supplement used for pain and inflammation is honokiol. Chinese traditional medicine has a long history of using magnolia bark to deal with different types of body pains and inflammation. In the laboratory, Honokiol has been found to reduce the pain-licking behavior of animal models. The effect comes from its ability to block pain responses and decrease inflammatory chemicals like the tumor necrosis factor.
Can Benefit Cancer PatientsCancer is becoming one of the top causes of morbidity worldwide. With the increasing number of people suffering from it, there is a greater call to find a natural alternative to commonly used chemotherapeutic drugs.
In different studies, honokiol induces apoptosis or programmed cell death among carcinoma cells. It has been well studied against leukemia, pancreatic, breast, and prostate cancer. Its anti-migration property helps prevent cancer from spreading to other areas of the body. Honokiol targets multiple signaling pathways to stop cancer initiation and progression by activating the AMPK, a regulator of cellular homeostasis. With relatively low toxicity levels, it is a promising treatment to control cancer progression.
Honokiol Extract Application:Pharmaceutical hygiene products and antimicrobial agentsMagnolol, the active component of magnolia officinalis extract, can be used as an antibacterial agent (gram-negative bacteria and acid-resistant bacteria) and can be used to prevent and treat acne
Daily chemical wash and care applicationOral hygiene products to fight tooth decay, inhibit tooth decay. The inhibition of Magnolol on NF-cB cells proved to improve the function of skin immune cells and had anti-inflammatory effect.
Cosmetic applicationsThe inhibition of Magnolol on NF-cB cells proved to improve the function of skin immune cells and had anti-inflammatory effect. Magnolol can also be used as an antioxidant and skin whitening agent.
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