Minoxidil

Minoxidil

CBNumber：CB7383531
MF： C9H15N5O
MW： 209.25
CAS： 38304-91-5

Melting point: 272-274 ° C (dec) (lit.)
Boiling point: 348.61 ° C (roughestimate)
Density: 1.1651 (roughestimate)
The refractive index: 1.7610 (estimate)
Storage conditions: 2-8 ° C
Solubility: Slightlysolubleinwater solubleinmethanolandinpropyleneglycol.
Form neat acidity coefficient (pKa) 4.61 (at25 ℃)
Water solubility: SolubleinwChemicalbookater (2.2 mg/ml), 100% ethanol (29 mg/ml), propyleneglycol, acetone, DMSO (6.5 mg/ml), andmethanol.
Merck: 14620 3
InChIKey: ZFMITUMMTDLWHR UHFFFAOYSA – N
CAS databases: 38304-91-5 (CASDataBaseReference)
NIST chemical letter: interest Minoxidil (38304-91-5)

Minodir alias long pressure, mined, molecular and relative molecular mass C9H15N5O , 209.25, white or white crystalline powder, slightly soluble in water or chloroform, slightly soluble in ethanol, microChemicalbook dissolved in acetone, soluble in ice acetic acid. Can directly act on the walls of blood vessels, dilate small arteries, reduce peripheral resistance, so that blood pressure drops, but also increase heart rate and heart drainage, but its antihypertensive effect is significant and long-lasting than the sepsis.

Pharmacological effect:
Minodil directly expands the small artery, thus lowering the pressure, but the specific mechanism is not clear. This product does not expand small veins. The reduction of peripheral vascular resistance causes the reflexive heart rate to accelerate and the amount of blood excretion to increase. Renin activity increases after bucking, causing sodium retention. This product does not interfere with blood Chemicalbook tube motion reflexes, so there is no erect hypotension. Minotre is a common and effective drug for treating hair loss, but the target cells for its pharmacological effects and their effects are not very clear, and recent studies have shown that Minotre may promote hair growth in a number of ways.

use:
A blood pressure-lowering drug used in the treatment of stubborn, primary, or renal hypertension

An oral drug clinically used to lower blood pressure:
Minodil is a clinical oral drug used to lower blood pressure, also known as long-pressure, pyridine diamine, bucking, minol blood, belongs to the potassium channel open agent, can directly relax the smooth muscle of blood vessels, has a strong small artery dilation, so that peripheral resistance decreased, blood vessel dilation, blood pressure decreased, and no effect on the capacity of blood vessels, so it can promote venous reflux. At the same time, due to the reflexive regulation and positive frequency, the heart output and heart rate can be increased, but does not cause low blood pressure. Clinically used for the treatment of persistent hypertension and renal hypertension. It can also be used for other antihypertensive drugs with poor effect of severe hypertension, but need to be combined with diuretic drugs to avoid sodium retention, combined with β receptor blockers can increase its efficacy, adverse reactions reduced. Long-term use of Chemicalbook Minotrell may have a side effect, i.e. body hair may increase slightly with the continued use of the drug, such as arm sweats. However, it is generally within acceptable limits. Oral adverse reactions are: weight gain caused by sodium retention and lower limb edema, reflexive intercourse nerve excitement caused by palpitations and arrhythmia, hairiness and so on. The main adverse reactions of external preparations are: skin irritation, erythema, itching and other dermatitis reactions at the drug site. Although the amount of absorption in external preparations is very small, it cannot be ruled out that it has an effect on the condition of patients with a history of heart disease. Suffering from cerebrovascular disease, non-hypertension caused by heart failure, coronary heart disease, angina, myocardial infarction, heart fluid, renal dysfunction and other diseases, must be used with caution, the allergy to Minodil and patients with chromoblastoma to be disabled.